Tigecycline resistance in clinical isolates of Enterococcus faecium is mediated by an upregulation of plasmid-encoded tetracycline determinants tet(L) and tet(M).

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Abstract

Tigecycline represents one of the last-line therapeutics to combat multidrug-resistant bacterial pathogens, including VRE and MRSA. The German National Reference Centre for Staphylococci and Enterococci has received 73 tigecycline-resistant Enterococcus faecium and Enterococcus faecalis isolates in recent years. The precise mechanism of how enterococci become resistant to tigecycline remains undetermined. This study documents an analysis of the role of efflux pumps in tigecycline resistance in clinical isolates of Enterococcus spp.

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Journal ID (iso-abbrev): J. Antimicrob. Chemother.

Title: The Journal of antimicrobial chemotherapy

ISSN (Electronic): 1460-2091

ISSN (Print): 0305-7453

Publication date (Electronic): Apr 2016

Volume: 71

Issue: 4

Affiliations

[1 ] Division of Nosocomial Pathogens and Antibiotic Resistances, National Reference Centre for Staphylococci and Enterococci, Department of Infectious Diseases, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany.

[2 ] Division of Nosocomial Pathogens and Antibiotic Resistances, National Reference Centre for Staphylococci and Enterococci, Department of Infectious Diseases, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany benderj@rki.de.

[3 ] Division of Enteropathogenic Bacteria and Legionella, Department of Infectious Diseases, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany.

[4 ] Department of Life Sciences and Technology, Beuth University of Applied Sciences, Berlin, Germany Division of Infectious Diseases, University Medical Centre Freiburg, Freiburg, Germany.

[5 ] Environmental Microbiology, Technical University Berlin, Berlin, Germany.

Article

Publisher Item ID: dkv420

DOI: 10.1093/jac/dkv420

PubMed ID: 26682961

SO-VID: a2647295-4252-4211-94df-25739e24204c

Copyright © © The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Tigecycline resistance in clinical isolates of Enterococcus faecium is mediated by an upregulation of plasmid-encoded tetracycline determinants tet(L) and tet(M).

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