13
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      A Review of Evidence for a Therapeutic Application of Traditional Japanese Kampo Medicine for Oral Diseases/Disorders

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Kampo medicines prescribed by specialized medical practitioners and Japanese physicians have gradually reemerged in Japan as alternatives to Western medications. Kampo formulations are composed of several plant extracts and, as such, the broad variety of phytochemicals they contain likely act synergistically to provide their beneficial effects. Kampo medicines have traditionally been prescribed for a number of health conditions, including chronic hepatitis, bronchial asthma, anemia, etc. The aim of this article is to review the beneficial effects of Kampos with respect to oral health. Pertinent papers published between 1970 and 2017 were retrieved by searching in PubMed, ScienceDirect, Web of Science, and Scopus using key words followed by evaluation of the relevant articles. In vitro studies have identified a number of properties that give credence to the potential of Kampos for treating or preventing oral diseases/disorders. Given their anti-microbial and anti-inflammatory properties, they may be promising agents for controlling periodontal diseases, oral mucositis, xerostomia, and drug-induced gingival overgrowth. Since some oral diseases have a complex etiology that involves microbial pathogens and the host immune response, agents with dual functionality such as Kampo phytochemicals may offer a therapeutic advantage.

          Related collections

          Most cited references53

          • Record: found
          • Abstract: not found
          • Article: not found

          Bacterial interactions and successions during plaque development.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints.

            G Garlet (2010)
            Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the destruction of tooth-supporting structures, being the presence of periodontopathogens required, but not sufficient, for disease development. As a general rule, host inflammatory mediators have been associated with tissue destruction, while anti-inflammatory mediators counteract and attenuate disease progression. With the discovery of several T-cell subsets bearing distinct immunoregulatory properties, this pro- vs. anti-inflammatory scenario became more complex, and a series of studies has hypothesized protective or destructive roles for Th1, Th2, Th17, and Treg subpopulations of polarized lymphocytes. Interestingly, the "protective vs. destructive" archetype is usually considered in a framework related to tissue destruction and disease progression. However, it is important to remember that periodontal diseases are infectious inflammatory conditions, and recent studies have demonstrated that cytokines (TNF-α and IFN-γ) considered harmful in the context of tissue destruction play important roles in the control of periodontal infection. Therefore, in this review, the state-of-the-art knowledge concerning the protective and destructive roles of host inflammatory immune response will be critically evaluated and discussed from the tissue destruction and control-of-infection viewpoints.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen.

              Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis, an inflammatory disease that destroys the tissues supporting the tooth, eventually leading to tooth loss. Porphyromonas gingivalis has can locally invade periodontal tissues and evade the host defence mechanisms. In doing so, it utilizes a panel of virulence factors that cause deregulation of the innate immune and inflammatory responses. The present review discusses the invasive and evasive strategies of P. gingivalis and the role of its major virulence factors in these, namely lipopolysaccharide, capsule, gingipains and fimbriae. Moreover, the role of P. gingivalis as a 'keystone' biofilm species in orchestrating a host response, is highlighted. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
                Bookmark

                Author and article information

                Journal
                Medicines (Basel)
                Medicines (Basel)
                medicines
                Medicines
                MDPI
                2305-6320
                18 April 2018
                June 2018
                : 5
                : 2
                : 35
                Affiliations
                [1 ]Oral Ecology Research Group, Faculty of Dentistry, Université Laval, 2420 Rue de la Terrasse, Quebec City, QC G1V 0A6, Canada; marie-pier.veilleux.4@ 123456ulaval.ca
                [2 ]Department of Hygiene and Oral Health Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan; moriyama.satomi.1@ 123456tokushima-u.ac.jp (S.M.); hinode@ 123456tokushima-u.ac.jp (D.H.)
                [3 ]Department of Oral Health Science and Social Welfare, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan; yoshioka.masami@ 123456tokushima-u.ac.jp
                Author notes
                [* ]Correspondence: daniel.grenier@ 123456greb.ulaval.ca ; Tel.: +1-418-656-7341; Fax: +1-418-656-2861
                Article
                medicines-05-00035
                10.3390/medicines5020035
                6023475
                29670027
                a2891b49-bf8c-45b5-8242-9a985a05d781
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 27 March 2018
                : 14 April 2018
                Categories
                Review

                kampo,traditional medicines,herbal medicines,oral diseases,periodontal diseases,mucositis

                Comments

                Comment on this article