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      Serial assessment of the coagulation status of dogs with immune-mediated haemolytic anaemia using thromboelastography.

      Veterinary Journal (London, England : 1997)
      Anemia, Hemolytic, Autoimmune, blood, veterinary, Animals, Blood Coagulation Disorders, Dog Diseases, Dogs, Female, Male, Thrombelastography, methods

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          Abstract

          This study investigated the coagulation status of dogs with immune-mediated haemolytic anaemia (IMHA) over time. Thirty animals with primary IMHA were blood sampled on three occasions over a 5 day period and assays performed included prothrombin time, activated partial thromboplastin time, D-dimer and fibrinogen concentration, antithrombin activity and recalcified unactivated thromboelastography (TEG). Based on TEG, dogs with IMHA were significantly hypercoagulable vs. controls (P<0.001) and over the 5 day period, 3/4 of the TEG parameters reflected increased clotting kinetics (P ≤ 0.02). The 30 day survival of these patients was 80% and, at hospital admission, the TEG maximum amplitude (MA) was significantly higher in survivors than non-survivors (P=0.015). Each unit increase in MA was associated with an increased odds of 30 day survival of 1.13 (95%; CI 1.02-1.25). Based on TEG, most dogs with IMHA were hypercoagulable on admission and their clotting kinetics increased with time. Relative hypocoagulability identified by TEG at initial assessment was found to be a negative prognostic indicator. Copyright © 2011 Elsevier Ltd. All rights reserved.

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          Journal
          21514858
          10.1016/j.tvjl.2011.03.015

          Chemistry
          Anemia, Hemolytic, Autoimmune,blood,veterinary,Animals,Blood Coagulation Disorders,Dog Diseases,Dogs,Female,Male,Thrombelastography,methods

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