The development of flexible and wearable healthcare devices facilitates a real-time monitoring of body activities as well as detecting various biosignals, which provided useful information to manage one's health condition for personal health monitoring.
Flexible electronic devices that are lightweight and wearable are critical for personal healthcare systems, which are not restricted by time and space. To monitor human bio-signals in a non-invasive manner, skin-conforming, highly sensitive, reliable, and sustainable healthcare monitoring devices are required. In this review, we introduce flexible and wearable sensors based on engineered functional nano/micro-materials with unique sensing capabilities for detection of physical and electrophysiological vital signs of humans. In addition, we investigate key factors for the development of user-interactive healthcare devices that are customizable, wearable, skin-conforming, and monolithic (design), and have long-term monitoring capability with sustainable power sources. Finally, we describe potential challenges of developing current wearable healthcare devices for applications in fitness, medical diagnosis, prosthetics, and robotics.