Protection from avian influenza H5N1 virus infection with antibody-impregnated filters

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Abstract

There is worldwide concern over the possibility of a new influenza pandemic originating from the highly pathogenic avian H5N1 influenza viruses. We herein demonstrate that functional air filters impregnated with ostrich antibodies against the hemagglutinin of the H5N1 virus protect chickens from death by H5N1 transmission. These results suggest that the use of ostrich antibody-impregnated filters might be a powerful way to prevent the transmission of H5N1.

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Most cited references 13

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Avian flu: influenza virus receptors in the human airway.

Kyoko Shinya, Masahito Ebina, Shinya Yamada … (2006)

Although more than 100 people have been infected by H5N1 influenza A viruses, human-to-human transmission is rare. What are the molecular barriers limiting human-to-human transmission? Here we demonstrate an anatomical difference in the distribution in the human airway of the different binding molecules preferred by the avian and human influenza viruses. The respective molecules are sialic acid linked to galactose by an alpha-2,3 linkage (SAalpha2,3Gal) and by an alpha-2,6 linkage (SAalpha2,6Gal). Our findings may provide a rational explanation for why H5N1 viruses at present rarely infect and spread between humans although they can replicate efficiently in the lungs.

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Avian influenza A (H5N1) infection in humans.

John H Beigel, Jeremy Farrar, Aye Han … (2005)

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Probable person-to-person transmission of avian influenza A (H5N1).

Kumnuan Ungchusak, Prasert Auewarakul, Scott Dowell … (2005)

During 2004, a highly pathogenic avian influenza A (H5N1) virus caused poultry disease in eight Asian countries and infected at least 44 persons, killing 32; most of these persons had had close contact with poultry. No evidence of efficient person-to-person transmission has yet been reported. We investigated possible person-to-person transmission in a family cluster of the disease in Thailand. For each of the three involved patients, we reviewed the circumstances and timing of exposures to poultry and to other ill persons. Field teams isolated and treated the surviving patient, instituted active surveillance for disease and prophylaxis among exposed contacts, and culled the remaining poultry surrounding the affected village. Specimens from family members were tested by viral culture, microneutralization serologic analysis, immunohistochemical assay, reverse-transcriptase-polymerase-chain-reaction (RT-PCR) analysis, and genetic sequencing. The index patient became ill three to four days after her last exposure to dying household chickens. Her mother came from a distant city to care for her in the hospital, had no recognized exposure to poultry, and died from pneumonia after providing 16 to 18 hours of unprotected nursing care. The aunt also provided unprotected nursing care; she had fever five days after the mother first had fever, followed by pneumonia seven days later. Autopsy tissue from the mother and nasopharyngeal and throat swabs from the aunt were positive for influenza A (H5N1) by RT-PCR. No additional chains of transmission were identified, and sequencing of the viral genes identified no change in the receptor-binding site of hemagglutinin or other key features of the virus. The sequences of all eight viral gene segments clustered closely with other H5N1 sequences from recent avian isolates in Thailand. Disease in the mother and aunt probably resulted from person-to-person transmission of this lethal avian influenzavirus during unprotected exposure to the critically ill index patient. Copyright 2005 Massachusetts Medical Society.

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Author and article information

Journal

Journal ID (nlm-ta): Virol J

Title: Virology Journal

Publisher: BioMed Central

ISSN (Electronic): 1743-422X

Publication date Collection: 2011

Publication date (Electronic): 8 February 2011

Volume: 8

Page: 54

Affiliations

[1 ]Life Science Research Laboratories, Research & Development Management Headquarters, Fujifilm Corporation, 577 Ushijima, Kaisei-machi, Ashigarakami-gun, Kanagawa 258-8577, Japan

[2 ]Department of Animal Hygiene, Graduate School of Biology and Environmental Sciences, Kyoto Prefecture University, 1-5 Nakaragicho, Kyoto 606-8522, Japan

[3 ]Faculty of Veterinary Medicine, Bogor Agriculture University, JL. Agatis, Kampus IPB Darmaga, Bogor 16680, Indonesia

[4 ]National Kyushu Medical Center, 1-8-1 Chiyukihama, Chuo-Ku, Fukuoka 810-8563, Japan

Article

Publisher ID: 1743-422X-8-54

DOI: 10.1186/1743-422X-8-54

PMC ID: 3045345

PubMed ID: 21303494

SO-VID: a2ab900f-61f9-4355-9ec7-51af5bc4bedd

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Protection from avian influenza H5N1 virus infection with antibody-impregnated filters

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Abstract

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Decoding Infection and Transmission

Most cited references 13

Avian flu: influenza virus receptors in the human airway.

Avian influenza A (H5N1) infection in humans.

Probable person-to-person transmission of avian influenza A (H5N1).

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