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Investigation of multipotent postnatal stem cells from human periodontal ligament.
Byoung-Moo Seo
1 ,
Masako Miura ,
Stan Gronthos ,
Peter Mark Bartold ,
Sara Batouli ,
Jaime Brahim ,
Marian Young ,
Pamela Gehron Robey ,
Cun-Yu Wang ,
Songtao Shi
July 13 2004
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Abstract
Periodontal diseases that lead to the destruction of periodontal tissues--including periodontal ligament (PDL), cementum, and bone--are a major cause of tooth loss in adults and are a substantial public-health burden worldwide. PDL is a specialised connective tissue that connects cementum and alveolar bone to maintain and support teeth in situ and preserve tissue homoeostasis. We investigated the notion that human PDL contains stem cells that could be used to regenerate periodontal tissue.