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Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis.
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Abstract
We recently cloned a new human mesangium-predominant gene, megsin. Megsin is a novel member of the serine protease inhibitor (serpin) superfamily. To elucidate functional roles of this gene, we cloned megsin in rodents and investigated its role in a rat nephritis model.