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      The Relationship Between the Renal Arterial Perfusion Pressure and the Increase in Sodium Excretion which Occurs During an Infusion of Saline

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      Nephron

      S. Karger AG

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          Abstract

          (1) The isolated dog kidney was perfused at constant pressure in a bath with blood from an intact unrelated dog receiving an intravenous infusion of normal saline and vasopressin. (2) It was found that the increase in sodium excretion from the perfused kidney was related to the renal arterial perfusion pressure in that the higher the pressure the greater the increase in sodium excretion. (3) The increase in sodium excretion was not related to changes in creatinine clearance, direct renal blood flow, filtered sodium, potassium excretion and PAH extraction, or to the fall in packed cell volume. (4) There was a significant inverse correlation between the rise in sodium excretion and the fall in plasma protein concentration; the greatest rise in sodium excretion being associated with the least fall in plasma protein concentration. (5) It is suggested that the exaggerated sodium excretion of hypertensive subjects when given intravenous saline may in part be due to the direct effect of the raised arterial pressure on the kidney.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1965
          1965
          25 November 2008
          : 2
          : 1
          : 1-14
          Affiliations
          Department of Medicine, Charing Cross Hospital Medical School, Fulham Hospital, London
          Article
          179370 Nephron 1965;2:1–14
          10.1159/000179370
          14333376
          © 1965 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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