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      Haemopoietic stem-cell kinetics during continuous irradiation.

      International journal of radiation biology and related studies in physics, chemistry, and medicine

      Animals, Cesium Isotopes, Clone Cells, Dose-Response Relationship, Radiation, Erythrocytes, metabolism, Female, Gamma Rays, Hematopoietic Stem Cells, radiation effects, Iron, Iron Radioisotopes, Male, Mice, Mitosis, Radiation Effects, Spleen, cytology, Time Factors

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          Abstract

          Analysis of the kinetics of the biphasic response of haemopoietic stem cells to chronic low dose-rate irradiation indicates that a highly radiosensitive delay of entry into cell-cycle by Go cells may be responsible for the initial, apparently dose-rate-independent, phase of the dose-response curve. The second component of the curve appears to be the result of a combination of two factors: a relatively decreased differentiation demand on stem cells due to increased amplification in the transit-committed precursor cells, and a uniform shortening of the cell-cycle--including the S period--in the stem cells.

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          1078817

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