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      Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice.

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          Abstract

          Stress exposure produces excitotoxicity and neuroinflammation, contributing to the cellular damage observed in stress-related neuropathologies. The endocannabinoids provide a homeostatic system, present in stress-responsive neural circuits. Here, we have assessed the possible regulatory role of cannabinoid CB2 receptors in stress-induced excitotoxicity and neuroinflammation.

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          Author and article information

          Journal
          Br. J. Pharmacol.
          British journal of pharmacology
          1476-5381
          0007-1188
          Jun 2014
          : 171
          : 11
          Affiliations
          [1 ] Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; Instituto de Investigación Sanitaria Hospital 12 de Octubre, Madrid, Spain; Instituto UCM de Investigación en Neuroquímica, Madrid, Spain.
          Article
          10.1111/bph.12607
          24467609
          a3329c52-0c16-4119-a3c0-3124b5048e4a
          © 2014 The British Pharmacological Society.
          History

          CB2 receptor,CB2xP mice,JWH-133,brain frontal cortex,excitotoxicity,neuroinflammation,stress

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