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      Ginkgo biloba extracts-loaded starch nano-spheres: Preparation, characterization, and in vitro release kinetics

      , , , , ,
      International Journal of Biological Macromolecules
      Elsevier BV

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          Abstract

          Ginkgo as a promising edible material and herbal medicine has received much attention due to its abundant starch contents and functional ingredient ginkgo biloba extracts (GBEs). Many foreign scholars suggest that GBEs can effectively ameliorate the symptoms of mild memory impairment and Alzheimer's dementia. However, an insurmountable problem with application of the GBEs is its low bioavailability, which restricts its application in vivo. Considering the biocompatibility between GBEs and starch, we have prepared ginkgo and corn starch-based nano-carriers, and thereby loaded GBEs onto starch nano-spheres (SNPs) by nanoprecipitation. Compared with unloaded SNPs (201-250nm), the mean sizes of the monodispersed and spherical GBEs-loaded SNPs were 255-396nm. Moreover, the loading amounts of GBEs onto ginkgo, and corn SNPs were 0.661-1.045, and 0.560mg/mg, respectively. In addition, in artificial gastric and intestinal juices, the GBEs-loaded SNPs exhibited a better sustained release than free GBEs.

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          Author and article information

          Journal
          International Journal of Biological Macromolecules
          International Journal of Biological Macromolecules
          Elsevier BV
          01418130
          January 2018
          January 2018
          : 106
          : 148-157
          Article
          10.1016/j.ijbiomac.2017.08.012
          28780415
          a3368f87-c6d8-4c44-8b8e-454ff816506c
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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