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      Hypochlorhydria and Hypergastrinemia and Their Association with Gastrointestinal Bleeding in Undialyzed and Hemodialyzed Patients

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          Abstract

          In 15 undialyzed (UD) patients and 26 hemodialyzed (HD) patients, (1) basal and test meal-stimulated gastrin concentrations, (2) basal and pentagastrin-stimulated gastric acid outputs, and (3) endoscopic examinations were studied. Also studied were the morphological and functional differences of the gastrointestinal tract between UD and HD patients. HD patients had lower gastric acid outputs and higher circulating gastrin levels in the fasting state. After a test meal, the peak increment of serum gastrin in UD and HD patients occurred 30 and 60 min later, respectively, and the response was prolonged in each group. Endoscopic findings showed that the incidence of abnormalities in each group was very similar, that is, the most predominant lesions in each group were hemorrhagic and atrophic gastritis. The data suggested that the response to gastrin of parietal cell and the defensive mechanism of gastrointestinal mucosa in HD patients may be impaired.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1988
          1988
          09 December 2008
          : 50
          : 1
          : 10-13
          Affiliations
          Departments of Cardiology and Surgery, Jichi Medical School, Tochigi, Japan
          Article
          185109 Nephron 1988;50:10–13
          10.1159/000185109
          3262834
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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