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      Ocular biometric characteristics during the menstrual cycle

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          Abstract

          Purpose

          To determine the ocular biometric characteristics during the menstrual cycle using the optical low-coherence reflectometry (OLCR) biometry.

          Methods

          Twenty-two healthy women between the ages of 19 and 36 years with regular menstrual cycles were enrolled in this prospective study. Subjects with irregular menstrual cycles, those taking contraceptive pills, those with a history of ocular surgery or trauma, and women unable to cooperate with the ocular biometry device were excluded from this study. A complete ophthalmic examination was performed between 8.30 and 10.30 am for all participants. Also, central corneal thickness, axial length, anterior chamber depth, lens thickness, and keratometric measurements were made at the same time using the OLCR device. Measurements were taken at the beginning of the cycle (1–3 days), at ovulation (12–16 days), and at the end of the cycle (26–32 days).

          Results

          The mean age of the participants was 22.86±4.22 (range: 18–36) years. The difference in central corneal thickness, axial length, anterior chamber depth, lens thickness, and keratometry values were not statistically significant during the menstrual cycle.

          Conclusion

          The ocular biometric parameters did not significantly vary during the menstrual cycle according to the OLCR biometry.

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          Most cited references17

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          Sex hormone receptors in the human eye.

          Dissimilarities in ocular physiopathology exist between human males and females. These differences can be observed in the lacrimal and other eye-associated glands, the ocular surface, the crystalline lens, and the retinochoroid complexes. Literature on the subject revealed that because of sex steroid hormone (estrogen, progesterone, and androgen) actions, various physiological conditions, such as age, menstrual cycles, pregnancy, and menopause or andropause, where the hormone milieu changes, affect vision. Well-designed scientific studies are lacking on the subject, although such studies hold much potential value. This review analyzes the relatively new area of hormones and vision.
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            Sex-steroid imbalance in females and dry eye.

            Dry eye (DE) is a multifactorial disorder of the ocular surface unit that results in eye discomfort, visual disturbance and ocular surface damage. It is one of the most common complaints in daily ophthalmic practice. The risk of DE increases with age in both sexes, while its incidence is higher among females. In addition, the condition of menopause in aging women may also contribute to DE onset or worsening as a consequence of an overall hormonal imbalance. Sex hormones play a key role in ocular surface physiology and they impact differently on ocular surface tissues. Reduced estrogen levels were historically thought to be responsible in age-related DE onset but more recent investigations have reconsidered the role of androgens that are present and exert a protective function on the ocular surface. Hormone levels themselves, withdrawal changes in hormone levels, and the changes in hormone-receptor responsiveness are all important factors but it remains to be fully elucidated how estrogen or androgen insufficiency act alone or together in a combined imbalance or interplay to raise the risk of disease. The purpose of this review is to briefly outline current scientific evidence on the influence of androgens and estrogens, on the Lachrymal and Meibomian glands and on ocular surface epithelia including conjunctival goblet cells during reproductive and menopausal periods. The role of sex steroids is also discussed in relation to the pathogenesis of different forms of DE and Sjogren's syndrome (SS). The impact of systemic hormone therapy (HT) in DE post-menopausal women still appears as a controversial issue, despite the many clinical studies. Finally, the outcomes of topical applications of steroid-based products are summarized, underlying the need for potential (tear) biomarker(s) in the rationale of DE-targeted therapy.
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              The effect of cycloplegia on the lenstar and the IOLMaster biometry.

              To evaluate the effect of cycloplegia on ocular biometry measurements and intraocular lens (IOL) power calculation using the Lenstar LS900 (Haag-Streit AG, Koeniz, Switzerland) and the IOLMaster (Carl Zeiss Meditec AG, Jena, Germany) biometers and to assess the agreement between the devices.
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                Author and article information

                Journal
                Clin Ophthalmol
                Clin Ophthalmol
                Clinical Ophthalmology
                Clinical Ophthalmology (Auckland, N.Z.)
                Dove Medical Press
                1177-5467
                1177-5483
                2015
                29 June 2015
                : 9
                : 1177-1180
                Affiliations
                [1 ]Department of Ophthalmology, Adnan Menderes University Medical Faculty, Aydın, Turkey
                [2 ]Department of Midwifery, School of Health, Adnan Menderes University Medical Faculty, Aydın, Turkey
                Author notes
                Correspondence: Harun Çakmak, Department of Ophthalmology, Adnan Menderes University Medical Faculty, Merkez Kampus Kepez Mevkii, 09100, Aytepe, Aydın, Turkey, Tel +90 544 440 0626, Fax +90 256 214 4086, Email dharuncakmak@ 123456gmail.com
                Article
                opth-9-1177
                10.2147/OPTH.S85160
                4494628
                a3608292-fbc9-45bd-8ad2-8293111b333e
                © 2015 Çakmak et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

                The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Original Research

                Ophthalmology & Optometry
                ocular biometry,olcr,menstrual cycle
                Ophthalmology & Optometry
                ocular biometry, olcr, menstrual cycle

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