Recent Advances in Hydrogel-Based Sensors Responding to Ionizing Radiation

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Abstract

Ionizing radiation and its applications are widely spread throughout life. Similar to many other things, both the positive and negative aspects of ionizing radiation should always be kept in mind. For example, a proper radiation dose can be delivered to tumor tissue to kill malignant cells in radiotherapy. On the other hand, exceeding this dose can damage the normal tissues of a human organism. Therefore, the application of sensors for measuring ionizing radiation doses is of utmost importance in many fields, especially in cancer therapy. Traditional dosimeters, such as ionization chambers, silicon diodes and thermoluminescence dosimeters, are widely used. However, they have limitations in certain aspects. Hydrogel-based sensors (or dosimeters) for measuring ionizing radiation doses attract extensive attention for decades due to their equivalence to living tissue and biocompatibility. In this review, we catalog hydrogel-based dosimeters such as polymer, Fricke, radio-chromic, radio-fluorescence and NPs-embedded dosimeters. Most of them demonstrate desirable linear response and sensitivity regardless of energy and dose rate of ionizing radiation. We aim to review these dosimeters and their potential applications in radiotherapy as well as to stimulate a joint work of the experts from different fields such as materials science, chemistry, cancer therapy, radiobiology and nuclear science.

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Polymer gel dosimetry.

L Schreiner, G Ibbott, A Jirasek … (2010)

Polymer gel dosimeters are fabricated from radiation sensitive chemicals which, upon irradiation, polymerize as a function of the absorbed radiation dose. These gel dosimeters, with the capacity to uniquely record the radiation dose distribution in three-dimensions (3D), have specific advantages when compared to one-dimensional dosimeters, such as ion chambers, and two-dimensional dosimeters, such as film. These advantages are particularly significant in dosimetry situations where steep dose gradients exist such as in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery. Polymer gel dosimeters also have specific advantages for brachytherapy dosimetry. Potential dosimetry applications include those for low-energy x-rays, high-linear energy transfer (LET) and proton therapy, radionuclide and boron capture neutron therapy dosimetries. These 3D dosimeters are radiologically soft-tissue equivalent with properties that may be modified depending on the application. The 3D radiation dose distribution in polymer gel dosimeters may be imaged using magnetic resonance imaging (MRI), optical-computerized tomography (optical-CT), x-ray CT or ultrasound. The fundamental science underpinning polymer gel dosimetry is reviewed along with the various evaluation techniques. Clinical dosimetry applications of polymer gel dosimetry are also presented.

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Measurement of radiation dose distributions by nuclear magnetic resonance (NMR) imaging.

Y Kang, Thomas R. Schulz, Christopher J. Gore (1984)

A method is described for determining the spatial distribution of radiation dose in a tissue-equivalent phantom using nuclear magnetic resonance imaging. The conversion of ferrous ions to ferric by ionising radiation alters the magnetic moment and electron spin relaxation times of the metal ion. The spin relaxation times (T1 and T2) of the hydrogen nuclei in an aqueous solution of a ferrous salt are consequently reduced substantially. These changes in T1 and T2 can be measured using standard NMR techniques. The same conversion is used in conventional Fricke dosimetry, which can be used to calibrate the technique.

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Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere.

P Bee Fong, Anthony Keil, Ronald Does … (2001)

Polymer gels whose NMR and optical properties change when irradiated offer unique advantages for measuring radiation dose distributions. To date, all acrylic polymer gel dosimeters must be manufactured, stored and irradiated in hypoxic conditions which severely limits their use and stability. A new formulation of acrylic dosimeter gel has been developed that responds well in normal atmosphere and which we have named MAGIC (Methacrylic and Ascorbic acid in Gelatin Initiated by Copper). To produce dosimeter gels, an aqueous solution of gelatin, open to the atmosphere, is mixed with methacrylic acid, copper(II) ions, ascorbic acid and hydroquinone. It is believed that the copper(II) and ascorbic acid form a complex with oxygen which (with radiolysis of water) serves as a free radical source for the initiation of the polymerization of methacrylic acid. At room air the water proton spin relaxation rate R2 in MAGIC gels is proportional to absorbed dose though the precise relationship depends on the composition of the gel and the initiating complex. For example, in the range 0-30 Gy the slope of the response of R2 versus dose at 20 MHz was 0.300, 0.519 and 0.681 s(-1) Gy(-1), respectively, when the concentration of MAA was 3, 6 and 9%. The slopes increased to 0.310, 0.567 and 0.868 s(-1) Gy(-1) at 85 MHz. An important determinant of the sensitivity to detect small dose changes is shown to be the slope-to-intercept ratio of the dose-response curve. These varied from 0.08 to 0.17, comparable to hypoxic gels described earlier. MAGIC gels can be manufactured and used much more easily than the previous formulations and can be imaged by magnetic resonance imaging or optical scanning, and thus they will likely be of considerable interest to radiation physicists.