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      ‘Ultrashort’ Feedback Control of Follicle-Stimulating Hormone-Releasing Factor Secretion

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          Abstract

          Subcutaneous administration of crude rat hypothalamic extracts containing FSH-RF and devoid of any FSH and sex steroid contamination gives rise to a considerable reduction of FSH- RF stores in the hypothalamus of castrated-hypophysectomized rats. It is suggested that the brain contains receptors sensitive to circulating levels of FSH-RF and, possibly, of other releasing factors; it is also postulated that FSH-RF might directly regulate its own production, through what might be called an ‘ultrashort’ feedback effect.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1971
          1971
          19 March 2008
          : 7
          : 4
          : 227-235
          Affiliations
          Department of Pharmacology, University of Milan, Milan
          Article
          121971 Neuroendocrinology 1971;7:227–235
          10.1159/000121971
          4927852
          © 1971 S. Karger AG, Basel

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          Pages: 9
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