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      ‘Ultrashort’ Feedback Control of Follicle-Stimulating Hormone-Releasing Factor Secretion

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          Abstract

          Subcutaneous administration of crude rat hypothalamic extracts containing FSH-RF and devoid of any FSH and sex steroid contamination gives rise to a considerable reduction of FSH- RF stores in the hypothalamus of castrated-hypophysectomized rats. It is suggested that the brain contains receptors sensitive to circulating levels of FSH-RF and, possibly, of other releasing factors; it is also postulated that FSH-RF might directly regulate its own production, through what might be called an ‘ultrashort’ feedback effect.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1971
          1971
          19 March 2008
          : 7
          : 4
          : 227-235
          Affiliations
          Department of Pharmacology, University of Milan, Milan
          Article
          121971 Neuroendocrinology 1971;7:227–235
          10.1159/000121971
          4927852
          a371a73e-e3d5-4a49-a111-42b9c188016e
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 01 June 1970
          : 14 August 1970
          Page count
          Pages: 9
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          FSH-RF secretion,Hypophysectomy,Feedback mechanism,Hypothalamic extracts,Castration

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