3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Topical 3% tranexamic acid enhances the efficacy of 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser in the treatment of melasma.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background: A QS-NdYAG laser (QSNYL) and topical tranexamic acid (TA) have been widely used. However, no study has yet reported the efficacy of using both QSNYL and TA as a combined treatment for melasma. Objectives: To evaluate the efficacy and adverse effects of topical 3% TA combined with 1064-nm QSNYL as a treatment for melasma. Methods: A randomized, prospective, split-face, controlled trial was conducted. A 1064-nm QSNYL was performed on the entire face at baseline and 4 weeks later. The participants were randomly selected for application of topical 3% TA on one side of the face and the vehicle treatment on the other side of the face for 8 weeks. Clinical responses were determined by mMASI scores, Mexameter™, and participants' evaluation. Results: Twenty-five participants completed the study. At the end of the study, the mMASI score significantly decreased in the combination treatment (p < 0.05), while no significant changes were observed in the laser-alone treatment. More than 80% of the participants noticed a >50% improvement on the side with combination therapy at every follow-up visit. No serious adverse events were reported. Conclusion: Topical TA as an adjuvant demonstrated trends of better outcomes than QSNYL alone for the treatment of melasma.

          Related collections

          Author and article information

          Journal
          J Cosmet Laser Ther
          Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
          Informa UK Limited
          1476-4180
          1476-4172
          Oct 2018
          : 20
          : 6
          Affiliations
          [1 ] a Division of Dermatology, Chulabhorn International College of Medicine , Thammasat University , Pathumthani , Thailand.
          Article
          10.1080/14764172.2018.1427869
          29461121
          a396f6ac-5fac-4868-8735-fabbe817c05f
          History

          1064 nm Q-switched Nd: YAG laser,tranexamic acid,Melasma

          Comments

          Comment on this article