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      Reliability of Entire Corneal Thickness Mapping in Normal Post-Laser in situ Keratomileusis and Keratoconus Eyes Using Long Scan Depth Spectral Domain Optical Coherence Tomography

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          Abstract

          Purpose: To investigate the repeatability and reproducibility of mapping the entire corneal thickness using spectral domain optical coherence tomography (SD-OCT). Methods: Thirty normal eyes, 30 post-laser in situ keratomileusis (LASIK) surgery eyes, and 30 keratoconus eyes were analyzed. A custom-built long scan depth SD-OCT device was used to obtain entire corneal images. Ten-millimeter-diameter corneal thickness maps were generated by an automated segmentation algorithm. Intraclass correlation coefficients of repeatability (ICC<sub>1</sub>) and reproducibility (ICC<sub>2</sub>), and coefficients of repeatability (CoR<sub>1</sub>) and reproducibility (CoR<sub>2</sub>), were calculated to quantify the precision and accuracy of corneal pachymetry measurements using the Bland-Altman method. Results: For SD-OCT measurements in healthy subjects, CoR<sub>1</sub> and CoR<sub>2</sub> were less than 5.00 and 5.53 μm. ICC<sub>1</sub> and ICC<sub>2</sub> were more than 0.997 and 0.996. For SD-OCT measurements in LASIK patients, CoR<sub>1</sub> and CoR<sub>2</sub> were less than 5.09 and 5.34 μm. ICC<sub>1</sub> and ICC<sub>2</sub> were more than 0.997 and 0.996. For SD-OCT measurements in keratoconus patients, CoR<sub>1</sub> and CoR<sub>2</sub> were less than 11.57 and 10.92 μm. ICC<sub>1</sub> and ICC<sub>2</sub> were more than 0.995 and 0.996. Conclusions: The measurements of corneal pachymetric mapping by long scan depth SD-OCT can be assessed over the entire corneal area with good repeatability and reproducibility.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          2018
          April 2018
          19 August 2017
          : 59
          : 3
          : 115-125
          Affiliations
          School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China
          Author notes
          *Yuanyuan Wang, MD, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027 (China), E-Mail wswzwyy@126.com
          Article
          478985 Ophthalmic Res 2018;59:115–125
          10.1159/000478985
          28848137
          a3a42e2a-97b2-4fea-ad26-a3fbb3b02b3a
          © 2017 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 4, Tables: 3, References: 62, Pages: 11
          Categories
          Original Paper

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