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Prime-boost interval matters: a randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect.
Julie E Ledgerwood
1 ,
Kathryn Zephir ,
Zonghui Hu ,
Chih-Jen Wei ,
Leejah Chang ,
Mary E Enama ,
Cynthia S Hendel ,
Sandra Sitar ,
Robert T Bailer ,
Richard A Koup ,
John R Mascola ,
Gary J Nabel ,
Barney S Graham
Aug 1 2013
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Abstract
H5 DNA priming was previously shown to improve the antibody response to influenza A(H5N1) monovalent inactivated vaccine (MIV) among individuals for whom there was a 24-week interval between prime and boost receipt. This study defines the shortest prime-boost interval associated with an improved response to MIV.