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      Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

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          Abstract

          This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and operational hurdles that prevent the utilisation of aerobic oxidation reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs).

          Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and operational hurdles that prevent the utilisation of aerobic oxidation reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs). The safety aspects of these reactions are discussed, followed by an overview of (continuous flow) reactors suitable for aerobic oxidation reactions that can be applied on scale. Some examples of how these reactions are currently performed in the industrial laboratory (in batch and in flow) are presented, with particular focus on the scale-up strategy. Last but not least, further challenges and future perspectives are presented in the concluding remarks.

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          CHEM21 selection guide of classical- and less classical-solvents

          A methodology, based on a combination of SH&E criteria, enables a simplified greenness evaluation of any solvent, in the context of fine or pharmaceutical chemistry.
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            Molecular Separation with Organic Solvent Nanofiltration: A Critical Review

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              Analysis of the reactions used for the preparation of drug candidate molecules.

              The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R&D departments of GlaxoSmithKline, AstraZeneca and Pfizer.
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                Author and article information

                Journal
                RCEEBW
                Reaction Chemistry & Engineering
                React. Chem. Eng.
                Royal Society of Chemistry (RSC)
                2058-9883
                2016
                2016
                : 1
                : 6
                : 595-612
                Article
                10.1039/C6RE00155F
                a3afe615-782d-4c01-ba10-d00796983a76
                © 2016
                History

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