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      Interaction of Ascorbate and ?-Tocopherol

      Annals of the New York Academy of Sciences

      Wiley-Blackwell

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          Most cited references 12

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          Direct observation of a free radical interaction between vitamin E and vitamin C.

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            Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function

             K U Ingold,  G. Burton (2002)
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              Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes.

              Thermally labile azo-initiators, dissolved in either the aqueous or lipid phase, have been used to generate peroxyl radicals at a known, steady rate in an aqueous dispersion of dilinoleoylphosphatidylcholine multilamellar liposomes at 37 degrees C in order to study the antioxidant behaviour of ascorbate itself and ascorbate in combination with either alpha-tocopherol or a water-soluble alpha-tocopherol analogue (TROLOX(-]. It is found that ascorbate is an effective inhibitor of peroxidations initiated in the aqueous phase, with each ascorbate terminating 0.6 radical chains (i.e., n = 0.6), but it is a very poor inhibitor of peroxidations initiated in the lipid phase. Peroxidations initiated in the lipid-phase in the presence of either alpha-tocopherol or TROLOX(-) indicate that ascorbate is an excellent synergist with both phenolic antioxidants (n = 0.4). In peroxidations initiated in the aqueous phase ascorbate acts as a co-antioxidant with TROLOX(-) (n = 0.7), but the interpretation of the approximately additive effect obtained in the presence of alpha-tocopherol is complicated by the fact that under the experimental conditions employed alpha-tocopherol alone does not give a distinct, measurable inhibition period. The latter problem is shown to be due to a non-uniform distribution of the water-soluble initiator within the liposome. Other examples of the complicating effects of non-uniform distributions of reactants in kinetic studies of the autoxidation of organic substrates dispersed in water are described.
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                Author and article information

                Journal
                Annals of the New York Academy of Sciences
                Ann NY Acad Sci
                Wiley-Blackwell
                0077-8923
                1749-6632
                July 1987
                July 1987
                : 498
                : 1 Third Confere
                : 186-199
                Article
                10.1111/j.1749-6632.1987.tb23761.x
                © 1987

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