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      Effect of Aldosterone on the Serum Zinc, Copper, and Magnesium Concentrations in the Rat

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          Possible regulation of trace metal metabolism by various steroid hormones has been reported by a number of investigators. The purpose of the present study was to determine the effect of aldosterone on the serum copper, zinc, and magnesium concentrations in the rat. Male and female rats were infused with aldosterone for up to 72 h and the serum copper, zinc, and magnesium concentrations were determined. The serum zinc concentration exhibited a transient decrease with a nadir at 24 h. No significant change was observed in serum magnesium or copper that was directly attributable to aldosterone. The mechanism by which aldosterone affects the transient serum zinc decrease was not demonstrated, but several possibilities were discussed.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 20
          : 3
          : 192-196
          aLevi National Arthritis Hospital, Hot Springs, Ark., and School of Pharmacy, Southwestern Oklahoma State University, Weatherford, Okla.; bCollege of Pharmacy, University of Arkansas for Medical Science, Little Rock, Ark.; cCollege of Pharmacy, Xavier University of Louisiana, New Orleans, La., USA
          179995 Horm Res 1984;20:192–196
          © 1984 S. Karger AG, Basel

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          Pages: 5


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