The fructose level of the corneal epithelium was found to be almost half the values of the glucose and decreased after cyclodiathermy. Low glucose levels – induced by partial cyclodiathermy – could be raised considerably by intravenous infusion of glucose. In order to avoid the side effects of the glucose infusion, fructose infusion was substituted. In the treated and untreated fellow eyes, the fructose levels in the corneal stroma and in the aqueous were markedly increased. The glucose levels were also elevated. It is suggested that fructose infusionmay be of value as nutrient metabolite of the cornea.