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      (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities.

      Journal of Natural Products
      Animals, Anti-Bacterial Agents, chemical synthesis, pharmacology, Antineoplastic Agents, Diterpenes, chemistry, Drug Resistance, Multiple, Drug Screening Assays, Antitumor, Mice, Microbial Sensitivity Tests, Molecular Structure, Porifera, Purines, Stereoisomerism, Tumor Cells, Cultured

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          Abstract

          An improved synthesis of (+)-agelasine D (10) from (+)-manool is reported together with cytotoxic and antibacterial data for agelasine D and structurally close synthetic analogues. These compounds display a broad spectrum of antibacterial activities including effects on M. tuberculosis and Gram-positive and Gram-negative bacteria (both aerobes and anaerobes). They exhibit profound cytotoxic activity against several cancer cells, including a multidrug-resistant cell line. (+)-Agelasine D (10) has been isolated earlier from a marine sponge (Agelas sp.).

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