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      Serum Secretory IgA and IgM and Free Secretory Component in IgA Nephropathy

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          Abstract

          IgA nephropathy (IgAN) is characterized by the presence of IgA and C3 deposits in the mesangium. Mesangial IgA is mostly dimeric IgAl with a J chain, lacking a secretory component. In view of the recent demonstration of elevated serum levels of secretory component and secretory IgA in liver disease and HIV infection associated with hyper-IgA, we measured the serum secretory component in 50 IgAN patients and 45 controls. Free secretory component and secretory IgA and IgM levels were determined by enzyme-linked immunosorbent assay. Normal or low levels were found in IgAN patients. These data support previous work suggesting that in IgAN circulating and probably mesangial IgA do not originate from the epithelial compartment of the mucosal immunoglobulins as it is the case in other hyper-IgA diseases.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1995
          1995
          18 December 2008
          : 71
          : 1
          : 75-78
          Affiliations
          aGRIP, Jeune Equipe DRED 251, Laboratoire d’Immunologie, Faculté de Médecine, CHU Nancy, bService de Néphrologie, CHU Nancy, cLaboratoire d’Immunologie, Faculté de Médecine et de Pharmacie, Besançon, dInserm U80, Hôpital E.-Herriot, Lyon, France
          Article
          188677 Nephron 1995;71:75–78
          10.1159/000188677
          8538852
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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