Resveratrol alleviates lung ischemia and reperfusion-induced pulmonary capillary injury through modulating pulmonary mitochondrial metabolism.

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Abstract

Lung ischemia and reperfusion (I/R) injury is one of the major causes of postoperative pulmonary dysfunction after cardiopulmonary surgery and thoracic organ transplantation. Recent studies suggest that lung I/R injury may be associated with defects in pulmonary mitochondrial function, in addition to damage from reactive oxygen species. In this study, we examined effects of one lung I/R injury on the other lung, and the protective efficacy of resveratrol on mitochondrial biogenesis in lungs.

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Journal

Journal ID (iso-abbrev): Transplant. Proc.

Title: Transplantation proceedings

ISSN (Electronic): 1873-2623

ISSN (Print): 0041-1345

Publication date (Electronic): May 2014

Volume: 46

Issue: 4

Affiliations

[1 ] Division of Chest Medicine, Internal Medicine, Shin Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan.

[2 ] School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.

[3 ] School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address: 078625@mail.fju.edu.tw.

Article

Publisher Item ID: S0041-1345(13)01308-0

DOI: 10.1016/j.transproceed.2013.11.094

PubMed ID: 24815145

SO-VID: a400a31a-aee3-4633-b0b1-67b76eaf2a8b

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