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      Relationship between Plasma and Tear Fluoride Levels in Rabbit and Man

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          Tear fluoride concentrations were determined in rabbits and man. Tear fluoride levels in reflex tears were higher in rabbits (2–10 µmol/l) than in man (1.4–4 µmol/l), while plasma levels were quite similar in both species (1.5–4 µmol/l). Chronic fluoride ingestion in rabbits over 29 days of 1, 5, 10, 25 or 50 (2.65 mmol/l) ppm fluoride in drinking water caused a dose-related increase in plasma, but not tear, levels of fluoride. The plasma:tear ratio went from 0.5 at baseline (1 ppm) to 1.8 after drinking water that contained 50 ppm F. Acute fluoride ingestion in man led to an increase in both plasma and tear fluoride levels that changed such that the plasmartear ratio remained constant despite a 2-fold increase in plasma fluoride.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          10 December 2009
          : 22
          : 1
          : 39-44
          Departments of aOral Biology-Physiology, bOphthalmology and cPhysiology and Endocrinology, Medical College of Georgia, Augusta, Ga., USA
          266999 Ophthalmic Res 1990;22:39–44
          © 1990 S. Karger AG, Basel

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          Pages: 6
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