Targeting Elastase for Molecular Imaging of Early Atherosclerotic Lesions.

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Abstract

Neutrophils accumulate in early atherosclerotic lesions and promote lesion growth. In this study, we evaluated an elastase-specific near-infrared imaging agent for molecular imaging using hybrid fluorescence molecular tomography/x-ray computed tomography.

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Journal

Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): March 2017

Volume: 37

Issue: 3

Affiliations

[1 ] From the Institut für diagnostische und interventionelle Radiologie, Klinikum rechts der Isar (A.G., M.A.K., F.L., K.K., M.W.), Klinik für vaskuläre und endovaskuläre Chirurgie, Klinikum rechts der Isar (A.G., J. Pelisek, H.-H.E.), Mechanics & High Performance Computing Group (M.P.T., M.W.G.), and Chair of Biological Imaging, Klinikum Rechts der Isar (V.N.), Technische Universität München, Germany; Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany (X.M., J. Prakash, V.N.); Institut für Experimentelle Biomedizin, Universitätsklinikum Würzburg, Germany (S.V., A.Z.); Rudolf Virchow Zentrum, Universität Würzburg, Germany (K.G.H.); and Translational Research Imaging Center, Universitätsklinikum Münster, Germany (M.W.).

[2 ] From the Institut für diagnostische und interventionelle Radiologie, Klinikum rechts der Isar (A.G., M.A.K., F.L., K.K., M.W.), Klinik für vaskuläre und endovaskuläre Chirurgie, Klinikum rechts der Isar (A.G., J. Pelisek, H.-H.E.), Mechanics & High Performance Computing Group (M.P.T., M.W.G.), and Chair of Biological Imaging, Klinikum Rechts der Isar (V.N.), Technische Universität München, Germany; Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany (X.M., J. Prakash, V.N.); Institut für Experimentelle Biomedizin, Universitätsklinikum Würzburg, Germany (S.V., A.Z.); Rudolf Virchow Zentrum, Universität Würzburg, Germany (K.G.H.); and Translational Research Imaging Center, Universitätsklinikum Münster, Germany (M.W.). moritz.wildgruber@ukmuenster.de.

Article

Publisher Item ID: ATVBAHA.116.308726

DOI: 10.1161/ATVBAHA.116.308726

PubMed ID: 28062502

SO-VID: a4032e73-a291-4912-b4b0-78a4ddb63957

History

Keywords: cardiovascular disease,fluorescence molecular tomography,imaging,neutrophils,arteriosclerosis

Data availability:

Keywords: cardiovascular disease, fluorescence molecular tomography, imaging, neutrophils, arteriosclerosis

Targeting Elastase for Molecular Imaging of Early Atherosclerotic Lesions.

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Abstract

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Electron Channelling Contrast Imaging (ECCI)

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