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      Influence of Humoral Factors on Renal Tubular Sodium Handling

      research-article
      Nephron
      S. Karger AG

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          Abstract

          From urine of orally hydrated normal persons a fraction was prepared by dialysis and ultrafiltration. This fraction, injected in normal and sodium depleted fasted rats, produced a dose-dependent increase in renal sodium excretion without change in renal potassium elimination. Glomerular filtration rate, renal plasma flow, and blood pressure are not affected by this urine fraction. Thus, the increase of natriuresis is the consequence of a diminished tubular sodium reabsorption, caused by the urine fraction applied. These results are interpreted as an evidence for a humoral natriuretic factor present in normal man after moderate oral hydration. Since urine preparations from patients with congestive heart failure fail to produce natriuresis in rats, it is concluded that insufficiency of this factor could be an explanation for the increased tubular sodium reabsorption and the development of edema in cardiac disease.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-0996-1
          978-3-318-02134-9
          1660-8151
          2235-3186
          1969
          1969
          26 November 2008
          : 6
          : 3
          : 205-216
          Affiliations
          Department of Medicine, Universität des Saarlandes, Homburg/Saar
          Article
          179729 Nephron 1969;6:205–216
          10.1159/000179729
          5791274
          a405b118-0aa1-4c83-ae63-89f40c47b38a
          © 1969 S. Karger AG, Basel

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          History
          Page count
          Pages: 12
          Categories
          Paper

          Cardiovascular Medicine,Nephrology
          Cardiovascular Medicine, Nephrology

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