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      Influence of Humoral Factors on Renal Tubular Sodium Handling

      Nephron

      S. Karger AG

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          Abstract

          From urine of orally hydrated normal persons a fraction was prepared by dialysis and ultrafiltration. This fraction, injected in normal and sodium depleted fasted rats, produced a dose-dependent increase in renal sodium excretion without change in renal potassium elimination. Glomerular filtration rate, renal plasma flow, and blood pressure are not affected by this urine fraction. Thus, the increase of natriuresis is the consequence of a diminished tubular sodium reabsorption, caused by the urine fraction applied. These results are interpreted as an evidence for a humoral natriuretic factor present in normal man after moderate oral hydration. Since urine preparations from patients with congestive heart failure fail to produce natriuresis in rats, it is concluded that insufficiency of this factor could be an explanation for the increased tubular sodium reabsorption and the development of edema in cardiac disease.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-0996-1
          978-3-318-02134-9
          1660-8151
          2235-3186
          1969
          1969
          26 November 2008
          : 6
          : 3
          : 205-216
          Affiliations
          Department of Medicine, Universität des Saarlandes, Homburg/Saar
          Article
          179729 Nephron 1969;6:205–216
          10.1159/000179729
          5791274
          © 1969 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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