Contributors
Yu Kato:
ORCID: http://orcid.org/0000-0003-1662-6983
Role: ConceptualizationRole: InvestigationRole: Project administrationRole: Writing
– original draft
Kimiyo Tabata: Role: Investigation
Takayuki Kimura: Role: InvestigationRole: Project administration
Ayako Yachie-Kinoshita: Role: InvestigationRole: Methodology
Yoichi Ozawa: Role: Investigation
Kazuhiko Yamada: Role: Investigation
Junichi Ito: Role: InvestigationRole: Methodology
Sho Tachino: Role: Investigation
Yusaku Hori: Role: Investigation
Masahiro Matsuki: Role: Investigation
Yukiko Matsuoka: Role: Supervision
Samik Ghosh: Role: Supervision
Hiroaki Kitano: Role: Supervision
Kenichi Nomoto: Role: SupervisionRole: Writing – review & editing
Junji Matsui: Role: SupervisionRole: Writing – review & editing
Yasuhiro Funahashi: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Fabrizio Mattei: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
27
February
2019
Publication date Collection: 2019
Volume: 14
Issue: 2
Electronic Location Identifier: e0212513
Affiliations
[1
]
Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan
[2
]
The Systems Biology Institute, Shinagawa, Tokyo, Japan
[3
]
Oncology Business Group, Eisai Inc., Woodcliff Lake, New Jersey, United States of
America
Istituto Superiore di Sanità, ITALY
Author notes
Competing Interests: Lenvatinib is the marketed product. YK, KT, and YH obtained the patent entitled “Combination
of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer”
(WO2016140717A1). These do not interfere with our adherence to PLOS ONE policies regarding
sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-18-29515
DOI: 10.1371/journal.pone.0212513
PMC ID: 6392299
PubMed ID: 30811474
SO-VID: a40e739e-43ef-4ad1-b4d0-9573f2216cb4
Copyright © © 2019 Kato et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 11
October
2018
Date
accepted
: 4
February
2019
Page count
Figures: 6,
Tables: 0,
Pages: 18
Funding
Eisai Co., Ltd. or Eisai Inc. provided support in the form of salaries for authors
(YK, KT, TK, JI, YO, KY, ST, YH, MM, JM, KN and YF), but did not have any additional
role in the study design, data collection and analysis, decision to publish, or preparation
of the manuscript. The specific roles of these authors are articulated in the ‘author
contributions’ section.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Blood cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Biology and life sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Medicine and health sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Spectrum Analysis Techniques
Subject:
Spectrophotometry
Subject:
Cytophotometry
Subject:
Flow Cytometry
Subject:
Research and Analysis Methods
Subject:
Histochemistry and Cytochemistry Techniques
Subject:
Immunohistochemistry Techniques
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunohistochemistry Techniques
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
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