Richard D. Boyce , PhD 1 , Isabelle Ragueneau-Majlessi , MD, MS 2 , Jingjing Yu , PhD 2 , Jessica Tay-Sontheimer , PhD 2 , Chris Kinsella 2 , Eric Chou , BS 1 , Mathias Brochhausen , PhD 3 , John Judkins , MS 3 , Brandon T. Gufford , PharmD, PhD 4 , Bruce E. Pinkleton , PhD 5 , Rebecca Cooney , MA 5 , Mary F. Paine , RPh, PhD 6 , Jeannine S. McCune , PharmD 7
05 December 2018
Pharmacokinetic interactions between natural products and conventional drugs can adversely impact patient outcomes. These complex interactions present unique challenges that require clear communication to researchers. We are creating a public information portal to facilitate researchers’ access to credible evidence about these interactions. As part of a user-centered design process, three types of intended researchers were surveyed: drug-drug interaction scientists, clinical pharmacists, and drug compendium editors. Of the 23 invited researchers, 17 completed the survey. The researchers suggested a number of specific requirements for a natural product-drug interaction information resource, including specific information about a given interaction, the potential to cause adverse effects, and the clinical importance. Results were used to develop user personas that provided the development team with a concise and memorable way to represent information needs of the three main researcher types and a common basis for communicating the design’s rationale.