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      Age-Related Changes of Water-Soluble Proteins of Human Eye Lens during the Prenatal Period

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          Abstract

          Saline extracts from human lenses were studied during prenatal eye development. Using immunodiffusion and immuno-electrophoresis with a specific antiserum against total extract of human adult lenses and monospecific antisera against the individual crystallin classes, it was established that alpha and beta crystallins were present in extracts from eye lenses from 5-week-old embryos while gamma crystallins could be detected in extracts from embryonic lenses at the beginning of the 6th gestational week. When analyzed by isoelectric focussing all alpha and beta crystallin components were found in extracts from 8-week-old embryos, while those of gamma crystallins were shown to appear successively within the period between the 8th and 14th gestational week. Some changes in the relative proportion of the different crystallin classes and subclasses were observed in the course of prenatal eye lens development between the 8th and 26th gestational week, as the percentage of alpha, high molecular weight and gamma crystallins was increased while the proportion of beta crystallins was gradually lowered.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1993
          1993
          11 December 2009
          : 25
          : 3
          : 162-171
          Affiliations
          Departments of aBiology, and bInternal Medicine II, Faculty of Medicine, Higher Institute of Medicine, and cInstitute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia, Bulgaria; dDepartment of Obstetrics and Gynecology, Higher Institute of Medicine, Pleven, Bulgaria
          Article
          267285 Ophthalmic Res 1993;25:162–171
          10.1159/000267285
          8336902
          a424aa99-465a-4ac6-9c1a-9ac20af141bb
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 09 August 1992
          : 07 December 1992
          Page count
          Pages: 10
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Human eye lens,Crystallins,Prenatal development

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