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      Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride

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          Abstract

          A novel molecular imprinting polymer (MIP) was prepared by bulk polymerization using sulpiride as the template molecule, itaconic acid (ITA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. The formation of the MIP was determined as the molar ratio of sulpiride-ITA-EGDMA of 1:4:15 by single-factor experiments. The MIP showed good adsorption property with imprinting factor α of 5.36 and maximum adsorption capacity of 61.13 μmol/g, and was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and surface area analysis. With the structural analogs (amisulpride, tiapride, lidocaine and cisapride) and small molecules containing a mono-functional group (p-toluenesulfonamide, formamide and 1-methylpyrrolidine) as substrates, static adsorption, kinetic adsorption, and rebinding experiments were also performed to investigate the selective adsorption ability, kinetic characteristic, and recognition mechanism of the MIP. A serial study suggested that the highly selective recognition ability of the MIP mainly depended on binding sites provided by N-functional groups of amide and amine. Moreover, the MIP as solid-phase extractant was successfully applied to extraction of sulpiride from the mixed solution (consisted of p-toluenesulfonamide, sulfamethoxazole, sulfanilamide, p-nitroaniline, acetanilide and trimethoprim) and serum sample, and extraction recoveries ranged from 81.57% to 86.63%. The tentative tests of drug release in stimulated intestinal fluid (pH 6.8) demonstrated that the tablet with the MIP–sulpiride could obviously inhibit sulpiride release rate. Thus, ITA-based MIP is an efficient and promising alternative to solid-phase adsorbent for extraction of sulpiride and removal of interferences in biosample analysis, and could be used as a potential carrier for controlled drug release.

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          Most cited references 42

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          Molecularly imprinted polymers for solid-phase extraction and solid-phase microextraction: recent developments and future trends.

          Molecularly imprinted polymers (MIPs) are synthetic polymers having a predetermined selectivity for a given analyte, or group of structurally related compounds, that make them ideal materials to be used in separation processes. In this sense, during past years a huge amount of papers have been published dealing with the use of MIPs as sorbents in solid-phase extraction, namely molecularly imprinted solid-phase extraction (MISPE). Although the majority of these papers were restricted to describe the use of different templates for different applications, several attempts proposing new alternatives to minimize the inherent drawbacks of the preparation and use of MIPs (i.e. template bleeding, tedious synthesis procedure, etc.) have been reported. Thus, this paper does not pretend to be a collection of MISPE-related papers but to give an overview on the significant attempts carried out during recent years to improve the performance of MIPs in solid-phase extraction. In addition, the use of MIPs packed in high performance liquid chromatography (HPLC) columns for the direct injection of crude sample extracts and the preparation of imprinted fibres for solid-phase microextraction will be also discussed.
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            Pharmacopoeia of the People’s Republic of China

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              Molecularly imprinted polymers: synthesis and characterisation.

              This short review aims to present, in clear English, a summary of the principal synthetic considerations pertaining to good practice in the polymerisation aspects of molecular imprinting, and is primarily aimed at researchers familiar with molecular imprinting methods but with little or no prior experience in polymer synthesis. It is our hope that this will facilitate researchers to plan their own syntheses of molecular imprints in a more logical and structured fashion, and to begin to appreciate the limitations of the present synthetic approaches in this molecularly complex area, as well as the scope for rationally designing improved imprinted materials in the future.
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Materials (Basel)
                Materials (Basel)
                materials
                Materials
                MDPI
                1996-1944
                28 April 2017
                May 2017
                : 10
                : 5
                Affiliations
                [1 ]School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China; gzzhangw@ 123456163.com
                [2 ]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; lab-shexuhui@ 123456kingmed.com.cn (X.S.); wangjiang0916@ 123456126.com (L.W.); kytxor@ 123456163.com (Q.Z.); xiaowenh25@ 123456126.com (X.H.)
                [3 ]Guangzhou KingMed Center for Clinical Laboratory Co., Ltd., Guangzhou 510005, China
                [4 ]China National Analytical Center Guangzhou, Guangzhou 510070, China
                [5 ]Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK; J.Z.Tang@ 123456wlv.ac.uk
                Author notes
                [* ]Correspondence: junhuafan@ 123456126.com ; Tel.: +86-020-3935-2135; Fax: +86-020-3935-2129
                Article
                materials-10-00475
                10.3390/ma10050475
                5459076
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

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