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      The Secretion of Parathyroid Hormone and Calcitonin

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          Factors which affect the secretion of parathyroid hormone (PTH) and calcitonin (CT) are subdivided into those which are nonspecific, those associated directly with ionic changes and those associated with changes in the intracellular concentration of cyclic AMP. Whereas PTH secretion is inversely related to both the concentrations of calcium and magnesium, CT secretion increases with increases in the plasma concentration of these ions. Cyclic AMP and both glucagon and adrenalin, at concentrations close to those found in normal animals, stimulate CT release in certain species but the alpha adrenergic component of adrenalin must first be blocked before the stimulatory effect of the beta adrenergic component is manifest. Speculation on the reason for the different effects of calcium and cyclic AMP in the two cells is centred on the possibility that they may have different intracellular concentrations of ionized calcium and that this may lead to an emphasis on hormone storage in the para-follicular cell and de novo hormone synthesis in the parathyroid chief cell.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 1
          : 6
          : 364-378
          Rowett Research Institute, Aberdeen
          178196 Hormones 1970;1:364–378
          © 1970 S. Karger AG, Basel

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          Pages: 15


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