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      Secolignans, neolignans and phenylpropanoids from Daphne feddei and their biological activities.

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          Abstract

          Two new secolignans and one new neolignan, named feddeiphenols A-C (1-3), together with eight known compounds (4-11), were isolated from the leaves and stems of Daphne feddei. Their structures were established on the base of spectroscopic methods, mainly extensive NMR, UV spectroscopy, and MS spectrometry. Compounds 1-11 were tested for their anti-human immunodeficiency virus (HIV)-1 activity and cytotoxicity. The results revealed that compounds 1, 2, 3, 7, and 9 showed therapeutic index (TI) values above 30, respectively, and the other compounds also showed weak anti-HIV-1 activity. Compound 1 showed modest cytotoxic activity. The other compounds also showed weak cytotoxic activity.

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          Author and article information

          Journal
          Chem. Pharm. Bull.
          Chemical & pharmaceutical bulletin
          1347-5223
          0009-2363
          2011
          : 59
          : 11
          Affiliations
          [1 ] Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, Kunming 650031, PR China.
          Article
          JST.JSTAGE/cpb/59.1421
          22041084
          a4421ce3-9a75-4f88-b542-9a9af13ac3f2
          History

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