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      A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

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      Behavioural Brain Research
      Elsevier BV

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          Abstract

          In this paper we describe a new memory test in rats, based on the differential exploration of familiar and new objects. In a first trial (T1), rats are exposed to one or to two identical objects (samples) and in a second trial, to two dissimilar objects, a familiar (the sample) and a new one. For short intertrial intervals (approximately 1 min), most rats discriminate between the two objects in T2: they spend more time in exploring the new object than the familiar one. This test has several interesting characteristics: (1) it is similar to visual recognition tests widely used in subhuman primates, this allows interspecies comparisons; (2) it is entirely based on the spontaneous behavior of rats and can be considered as a 'pure' working-memory test completely free of reference memory component; (3) it does not involve primary reinforcement such as food or electric shocks, this makes it comparable to memory tests currently used in man.

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          Author and article information

          Journal
          Behavioural Brain Research
          Behavioural Brain Research
          Elsevier BV
          01664328
          November 1988
          November 1988
          : 31
          : 1
          : 47-59
          Article
          10.1016/0166-4328(88)90157-X
          3228475
          a45531a3-7f1a-4b2f-9c14-e636a60dd70d
          © 1988

          https://www.elsevier.com/tdm/userlicense/1.0/

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