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Quartz crystal microbalance (QCM) sensors coated with molecular imprinted polymers
(MIP) have been developed for the determination of thymine. In this method, methacryloylamidoadenine
(MA-Ade) have used as a new monomer and thymine template for inspiration of DNA nucleobases
interaction. The thymine can be simultaneously hydrogen binding to MA-Ade and fit
into the shape-selective cavities. Thus, the interaction between nucleobases has an
effect on the binding ability of the QCM sensors. The binding affinity of the thymine
imprinted sensors has investigated by using the Langmuir isotherm. The thymine imprinted
QCM electrodes have shown homogeneous binding sites for thymine (K(a): 1.0 x 10(5)M(-1))
while heterogeneous binding sites for uracil. On the other hand, recognition selectivity
of the QCM sensor based on thymine imprinted polymer toward to uracil, ssDNA and ssRNA
has been reported in this work.