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Designing of MIP based QCM sensor having thymine recognition sites based on biomimicking DNA approach.

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Biosensors & bioelectronics

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      Abstract

      Quartz crystal microbalance (QCM) sensors coated with molecular imprinted polymers (MIP) have been developed for the determination of thymine. In this method, methacryloylamidoadenine (MA-Ade) have used as a new monomer and thymine template for inspiration of DNA nucleobases interaction. The thymine can be simultaneously hydrogen binding to MA-Ade and fit into the shape-selective cavities. Thus, the interaction between nucleobases has an effect on the binding ability of the QCM sensors. The binding affinity of the thymine imprinted sensors has investigated by using the Langmuir isotherm. The thymine imprinted QCM electrodes have shown homogeneous binding sites for thymine (K(a): 1.0 x 10(5)M(-1)) while heterogeneous binding sites for uracil. On the other hand, recognition selectivity of the QCM sensor based on thymine imprinted polymer toward to uracil, ssDNA and ssRNA has been reported in this work.

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      Affiliations
      [1 ] Department of Chemistry, Anadolu University, Fen Fakültesi, Kimya Bölümü, Yunus Emre Kampüsü, 26470 Eskişehir, Turkey. semir@anadolu.edu.tr
      Journal
      Biosens Bioelectron
      Biosensors & bioelectronics
      1873-4235
      0956-5663
      Nov 15 2009
      : 25
      : 3
      19250816 S0956-5663(09)00029-3 10.1016/j.bios.2009.01.032

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