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      Experimental Disciform Keratitis

      , ,
      Ophthalmic Research
      S. Karger AG
      Cornea, Hypersensitivity, Keratitis, Herpesvirus, Autoimmunity

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          A highly virulent strain of herpes simplex virus was injected intrastromally into previously immunized corneas of pigmented rabbits. After repeated injections with large doses of viable virus over a period of several months, it was found, with minor exceptions, that most corneas tolerated the virus after each injection, yielding clear corneas and very little deep stromal keratitis or edema.Disciform These results provide significant indirect evidence that disciform keratitis in animals does not develop as a result of hypersensitivity to viable whole virus particles. There remains the possibility that hypersensitivity to other antigens, such as soluble virus antigens, or autoimmunity to cellular antigenic components may be significant. These suggestions are discussed.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          July 2004
          09 December 2009
          : 4
          : 2
          : 99-109
          Wills Eye Research Institute, Philadelphia, Pa.
          265960 Ophthalmic Res 1972–73;4:99–109
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 30 March 1972
          : 24 April 1972
          Page count
          Pages: 11

          Vision sciences,Ophthalmology & Optometry,Pathology


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