+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Acute Estradiol and Progesterone Administration Reduced Cardiovascular and Catecholamine Responses to Mental Stress in Menopausal Women

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Steroid hormones are involved in the regulation of sympathoadrenal activity. Since the effect of sex steroids on the cardiovascular system and catecholamine secretion could also be exerted through an acute, nongenomic mechanism, we have studied the response to mental stress (color word test, CWT) in a group of 15 menopausal women during estrogen (100 µg of estradiol by patch), progesterone (100 mg i.m.) or placebo administration. Systolic blood pressure (SBP) increased during CWT in the three sessions (F = 11.0, p < 0.001) but the area under the curve of SBP was higher during placebo (2,855 ± 131 mm Hg·min) than during estradiol (2,585 ± 139 mm Hg·min) and progesterone (2,553 ± 179 mm Hg·min, p < 0.05 for both). Plasma epinephrine increased during CWT in the three sessions (F = 31.1, p < 0.001) and the plasma epinephrine response to mental stress was higher during placebo than during estradiol administration (F = 4.3, p < 0.01). The area under the curve of epinephrine was 10,342 ± 1,348 pmol/min·l during placebo and 7,280 ± 818 pmol/min·l during estradiol (p < 0.03). The plasma glycerol levels at the end of CWT were higher during placebo (0.26 ± 0.04 nmol/l) than during estradiol (0.19 ± 0.03 mmol/l) and progesterone (0.17 ± 0.04 mmol/l) administration (p < 0.05 for both). No significant differences were found in the responses of diastolic blood pressure, heart rate, norepinephrine and cortisol to mental stress during placebo and estradiol or progesterone administration. This study demonstrates that acute steroid administration is able to modify the cardiovascular and catecholamine response to mental stress in menopausal women.

          Related collections

          Most cited references 2

          • Record: found
          • Abstract: not found
          • Article: not found

          Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women

            • Record: found
            • Abstract: not found
            • Article: not found

            Functional heterogeneity among liver cells: implications for drug toxicity and metabolism

             G.D. Sweeney (1981)

              Author and article information

              S. Karger AG
              March 1998
              11 April 1998
              : 67
              : 3
              : 269-274
              a Cattedra di Malattie del Metabolismo, b Cattedra di Endocrinologia, c Cattedra di Ostetricia e Ginecologia, Modena, Italia
              54322 Neuroendocrinology 1998;67:269–274
              © 1998 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 4, Tables: 1, References: 39, Pages: 6
              Gonadotropins and Gonadal Steroids


              Comment on this article