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      National clinical practice guidelines for allergen immunotherapy: An international assessment applying AGREE-II

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          Most cited references18

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          Allergen immunotherapy: a practice parameter third update.

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            International consensus on allergy immunotherapy.

            Allergen immunotherapy (AIT) has been used to treat allergic disease since the early 1900s. Despite numerous clinical trials and meta-analyses proving AIT efficacious, it remains underused and is estimated to be used in less than 10% of patients with allergic rhinitis or asthma worldwide. In addition, there are large differences between regions, which are not only due to socioeconomic status. There is practically no controversy about the use of AIT in the treatment of allergic rhinitis and allergic asthma, but for atopic dermatitis or food allergy, the indications for AIT are not well defined. The elaboration of a wider consensus is of utmost importance because AIT is the only treatment that can change the course of allergic disease by preventing the development of asthma and new allergen sensitizations and by inducing allergen-specific immune tolerance. Safer and more effective AIT strategies are being continuously developed both through elaboration of new allergen preparations and adjuvants and alternate routes of administration. A number of guidelines, consensus documents, or both are available on both the international and national levels. The international community of allergy specialists recognizes the need to develop a comprehensive consensus report to harmonize, disseminate, and implement the best AIT practice. Consequently, the International Collaboration in Asthma, Allergy and Immunology, formed by the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma & Immunology; and the World Allergy Organization, has decided to issue an international consensus on AIT.
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              Is Open Access

              Sublingual immunotherapy: World Allergy Organization position paper 2013 update

              We have prepared this document, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update”, according to the evidence-based criteria, revising and updating chapters of the originally published paper, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2009”, available at http://www.waojournal.org. Namely, these comprise: “Mechanisms of sublingual immunotherapy;” “Clinical efficacy of sublingual immunotherapy” – reporting all the data of all controlled trials published after 2009; “Safety of sublingual immunotherapy” – with the recently published Grading System for adverse reactions; “Impact of sublingual immunotherapy on the natural history of respiratory allergy” – with the relevant evidences published since 2009; “Efficacy of SLIT in children” – with detailed analysis of all the studies; “Definition of SLIT patient selection” – reporting the criteria for eligibility to sublingual immunotherapy; “The future of immunotherapy in the community care setting”; “Methodology of clinical trials according to the current scientific and regulatory standards”; and “Guideline development: from evidence-based medicine to patients' views” – including the evolution of the methods to make clinical recommendations. Additionally, we have added new chapters to cover a few emerging crucial topics: “Practical aspects of schedules and dosages and counseling for adherence” – which is crucial in clinical practice for all treatments; “Perspectives and new approaches” – including recombinant allergens, adjuvants, modified allergens, and the concept of validity of the single products. Furthermore, “Raising public awareness about sublingual immunotherapy”, as a need for our patients, and strategies to increase awareness of allergen immunotherapy (AIT) among patients, the medical community, all healthcare stakeholders, and public opinion, are also reported in detail.
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                Author and article information

                Journal
                Allergy
                Allergy
                Wiley
                01054538
                March 2018
                March 2018
                October 17 2017
                : 73
                : 3
                : 664-672
                Affiliations
                [1 ]Investigational Unit; Hospital Medica Sur; Mexicocity Mexico
                [2 ]Servicio de Enfermedades del Sistema Inmune-Alergia; Hospital Universitario Príncipe de Asturias; Alcalá de Henares Spain
                [3 ]Departamento de Medicina y Especialidades Médicas; Universidad de Alcalá; Madrid Spain
                [4 ]Hospital Italiano de Buenos Aires; Buenos Aires Argentina
                [5 ]Royal Liverpool University Hospital and Liverpool Hope University; Liverpool United Kingdom
                [6 ]Universidad de Guadalajara; Guadalajara Mexico
                [7 ]Hannover Medical School; Hannover Germany
                [8 ]University Hospital of Salamanca; Salamanca Spain
                [9 ]Fundación Ayre (Education & Research); Salta Argentina
                [10 ]Red Cross Children's Hospital and School of Adolescent and Child Health; University of Cape Town; Cape Town South Africa
                [11 ]Universidad de Hidalgo; Pachuca Mexico
                [12 ]Center for Rhinology and Allergology; Wiesbaden Germany
                [13 ]Universidade Federal do Paraná; Curitiba Brazil
                [14 ]Padua University; Padua Italy
                [15 ]Department of Allergy & Clinical Immunology; Transylvania University; Brasov Romania
                [16 ]MACVIA-France; Contre les MAladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site; Montpellier France
                [17 ]Asthma UK Centre for Applied Research; Usher Institute of Population Health Sciences and Informatics; The University of Edinburgh; Scotland UK
                [18 ]Department of Otorhinolaryngology, Head and Neck Surgery; Universitätsmedizin Mannheim; Medical Faculty Mannheim; Heidelberg University; Mannheim Germany
                Article
                10.1111/all.13316
                28940450
                a47ff099-126d-43f2-a358-907b97d38b10
                © 2017

                http://doi.wiley.com/10.1002/tdm_license_1.1

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