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Abstract
Enhanced activity of the lipid peroxidation and oxidative damages have been implicated
in the pathogenesis of diabetic kidney complications. We explored to determine whether
these changes in diabetic kidney could be prevented by water extract of mixture of
Phellodendron cortex and Aralia cortex (P55A). Greatly elevated content of thiobarbituric
acid reactive substances (TBARS) and carbonylated protein in kidneys of diabetic rats
were significantly reduced by P55A treatment. In addition, abnormally low ratio of
GSH/GSSG in diabetic kidneys was elevated to almost normal levels by the treatment
with P55A. These results suggest that P55A extracts exert antioxidant effect by reducing
lipid peroxidation and protein carbonylation as well as by elevating the ratio of
GSF/GSSG in diabetic kidney.