The multistep genetic alterations thought to involve both oncogenes and tumor suppressor genes that are causally related to melanocytic transformation remain largely undetermined (1). Mapping of alterations to chromosome 6 indicates that multiple genetic loci on 6q contribute causally to the development and progression of malignant melanoma (1). This notion is also supported by the introduction of chromosome 6 in malignant melanoma cell lines suppressing either their tumorigenicity (2) or metastasis (3,4). However, the suppressor genes involved have yet to be identified.