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      Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression.

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          Abstract

          Retinoids are involved in cell differentiation, morphogenesis, proliferation and antineoplasic processes. Thus, the retonoic acid receptor (RARalpha) agonist, AM80, regulates tissue factor (TF), thrombomodulin (TM) expression and granulocytic differentiation in promyelocytic cells, while the RARgamma-selective retinoid, CD437, inhibits in vitro cell proliferation and induces apoptosis. The mitogen-activated protein kinase (MAPK) and the phosphatidylinositol-3-kinase (PI3K) pathways constitute key integration points along the signal transduction cascades that link diverse extracellular stimuli to proliferation, differentiation and survival.

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          Author and article information

          Journal
          Haematologica
          Haematologica
          1592-8721
          0390-6078
          Mar 2004
          : 89
          : 3
          Affiliations
          [1 ] Unidad de Investigación, Hospital Universitario Reina Sofía, Avda. Menéndez Pidal s/n, E-14004 Córdoba, Spain. rosario.lopez.exts@juntadeandalucia.es
          Article
          15020266
          a499db1e-8d35-4d77-b2d4-98b51b225b55
          History

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