Onosma anatolica Binzet, is described and illustrated as a new species from Niğde province in southern Anatolia, Turkey. It belongs to sect. Onosma L. subsect. Asterotricha (Boiss.) Gürke. The new species is closely related to Onosma subulifolia Riedl from which it is distinguished. O. anatolica is readily distinguished from O. subulifolia by its sterile shoots, the green-grey stem indumentum, longer bracts, yellow and puberulous petals. The IUCN threat category of O. anatolica is determined as “CR (Critically Endangered)”. A distribution map and anidentification key for O. anatolica and O. subulifolia supplement the study.