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      GH Secretion in Open-Angle Glaucoma

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          Open-angle glaucoma is frequently observed in patients with acromegaly suggesting that the somatotropic hormone might facilitate a condition of glaucoma. The open-angle glaucoma patients studied, displayed higher plasma human growth hormone (HGH) levels than control subjects 60 min (30.3 ± 1.7 against 16.8 ± 2.7 ng/ml; p < 0.001) and 90 min (19.0 ± 1.9 against 9.3 ± 1.2 ng/ml; p < 0.001) after intravenous administration of arginine (25 g in 30 min). The authors support the hypothesis that the increased plasma HGH level may interfere with the regulation of ocular pressure by modifying the flow of aqueous humor from the eyeball via changes in the sclero-corneal trabecular meshwork; these changes are also found in diabetic subjects. The interplay between HGH and changes of carbohydrate metabolism (frequently occurring in glaucomatous patients) may be at the root of the variations of intraocular pressure in open-angle glaucoma.

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          Author and article information

          S. Karger AG
          30 March 2010
          : 179
          : 3
          : 168-172
          Istituto di Patologia Medica and Department of Ophthalmology, Catholic University, Rome
          308886 Ophthalmologica 1979;179:168–172
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 5
          Original Paper

          Vision sciences, Ophthalmology & Optometry, Pathology

          GH secretion, Open-angle glaucoma


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