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      Haemodynamic Effects of Slow-Release Nifedipine in Severe Congestive Heart Failure due to Ischaemic Heart Disease

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      Cardiology

      S. Karger AG

      Congestive heart failure, Nifedipine, slow-release, Haemodynamic effects

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          Abstract

          Haemodynamic effects of nifedipine (NIF) tablets were studied for 12 h in 10 patients with severe congestive heart failure due to ischaemic heart disease. A significant reduction (p < 0.001) in systemic and pulmonary vascular resistances and pulmonary capillary wedge pressure, was observed, at rest and after hand grip exercise, while cardiac index and stroke volume index increased significantly (p < 0.001). Reductions in systolic and diastolic blood pressure and increases in heart rate were hardly significant. Variations were found between 8 and 10 h (confidence interval). The maximum NIF plasma concentration was 33.3 ± 27.2 ng/ml after 6 h. The improvement in cardiac performance produced by NIF tablets was of substantial duration with twice-daily administration.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1990
          1990
          12 November 2008
          : 77
          : 6
          : 450-458
          Affiliations
          Department of Cardiology, Ospedale Desenzano-Lonato, Desenzano del Garda, Brescia, Italy
          Article
          174637 Cardiology 1990;77:450–458
          10.1159/000174637
          2073662
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Original Paper

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