Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Inappropriate use of bivariable analysis to screen risk factors for use in multivariable analysis.

Journal of Clinical Epidemiology

Confounding Factors (Epidemiology), Coronary Artery Bypass, mortality, statistics & numerical data, Coronary Disease, epidemiology, Data Interpretation, Statistical, Female, Hospital Mortality, Humans, Male, Multivariate Analysis, Selection Bias, Risk Assessment, Risk Factors

Read this article at

ScienceOpenPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      The use of bivariable selection (BVS) for selecting variables to be used in multivariable analysis is inappropriate despite its common usage in medical sciences. In BVS, if the statistical p value of a risk factor in bivariable analysis is greater than an arbitrary value (often p = 0.05), then this factor will not be allowed to compete for inclusion in multivariable analysis. This type of variable selection is inappropriate because the BVS method wrongly rejects potentially important variables when the relationship between an outcome and a risk factor is confounded by any confounder and when this confounder is not properly controlled. This article uses both hypothetical and actual data to show how a nonsignificant risk factor in bivariable analysis may actually be a significant risk factor in multivariable analysis if confounding is properly controlled. Furthermore, problems resulting from the automated forward and stepwise modeling with or without the presence of confounding are also addressed. To avoid these improper procedures and deficiencies, alternatives in performing multivariable analysis, including advantages and disadvantages of the BVS method and automated stepwise modeling, are reviewed and discussed.

      Related collections

      Author and article information

      Journal
      8699212

      Comments

      Comment on this article