- Record: found
- Abstract: found
- Article: not found
Toward targeted oral vaccine delivery systems: selection of lectin mimetics from combinatorial libraries.
Imelda Lambkin
1 ,
Clemencia Pinilla ,
Christa Hamashin ,
Lisa Spindler ,
Shannon Russell ,
Amy Schink ,
Rosa Moya-Castro ,
Gina Allicotti ,
Lisa Higgins ,
Melanie Smith ,
Jackie Dee ,
Carolyn Wilson ,
Richard Houghten ,
Daniel O'Mahony
Aug 2003
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Various lectins bind specifically to oligosaccharides on intestinal cells. Exploiting this specificity, Ulex europaeus agglutinin I (UEA1) has been used as a ligand for targeted oral vaccine delivery to M cells (antigen-presenting cells) in follicle-associated epithelium. In this study we characterized compounds identified from mixture-based positional scanning synthetic combinatorial libraries, which mimic UEA1 and, thus, may have properties applicable to targeted drug delivery.