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      GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists

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          Abstract

          GENECODIS, a web-based tool for finding annotations that frequently co-occur in a set of genes and ranking them by their statistical significance, is presented.

          Abstract

          We present GENECODIS, a web-based tool that integrates different sources of information to search for annotations that frequently co-occur in a set of genes and rank them by statistical significance. The analysis of concurrent annotations provides significant information for the biologic interpretation of high-throughput experiments and may outperform the results of standard methods for the functional analysis of gene lists. GENECODIS is publicly available at http://genecodis.dacya.ucm.es/.

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          Most cited references17

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          Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

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            Gene Ontology: tool for the unification of biology

            Genomic sequencing has made it clear that a large fraction of the genes specifying the core biological functions are shared by all eukaryotes. Knowledge of the biological role of such shared proteins in one organism can often be transferred to other organisms. The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing. To this end, three independent ontologies accessible on the World-Wide Web (http://www.geneontology.org) are being constructed: biological process, molecular function and cellular component.
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              Entrez Gene: gene-centered information at NCBI

              Entrez Gene (www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene) is NCBI's database for gene-specific information. It does not include all known or predicted genes; instead Entrez Gene focuses on the genomes that have been completely sequenced, that have an active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. The content of Entrez Gene represents the result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. Records are assigned unique, stable and tracked integers as identifiers. The content (nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases) is updated as new information becomes available. Entrez Gene is a step forward from NCBI's LocusLink, with both a major increase in taxonomic scope and improved access through the many tools associated with NCBI Entrez.
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                Author and article information

                Journal
                Genome Biol
                Genome Biology
                BioMed Central (London )
                1465-6906
                1465-6914
                2007
                4 January 2007
                : 8
                : 1
                : R3
                Affiliations
                [1 ]BioComputing Unit, National Center of Biotechnology (CNB-CSIC), C/Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain
                [2 ]Computer Architecture Department, Facultad de Ciencias Físicas, Universidad Complutense de Madrid, C/Avenida Complutense S/N, 28040 Madrid, Spain
                Article
                gb-2007-8-1-r3
                10.1186/gb-2007-8-1-r3
                1839127
                17204154
                a4c267f8-b830-49e4-a00b-d582bfc1f9ca
                Copyright © 2007 Carmona-Saez et al.; licensee BioMed Central Ltd.

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 3 July 2006
                : 29 September 2006
                : 4 January 2007
                Categories
                Software

                Genetics
                Genetics

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