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      Long non-coding RNAs and cancer: a new frontier of translational research?

      1 , , ,
      Oncogene
      Springer Science and Business Media LLC

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          Abstract

          Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs and present a cancer-oriented list of lncRNAs, list some tools (for example, public databases) that classify lncRNAs or that scan genome spans of interest to find whether known lncRNAs reside there, and describe some of the functions of lncRNAs and the possible genetic mechanisms that underlie lncRNA expression changes in cancer, as well as current and potential future applications of lncRNA research in the treatment of cancer.

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          Author and article information

          Journal
          Oncogene
          Oncogene
          Springer Science and Business Media LLC
          1476-5594
          0950-9232
          Oct 25 2012
          : 31
          : 43
          Affiliations
          [1 ] Experimental Oncology, Centro di Riferimento Oncologico, IRCSS-National Cancer Institute, Aviano, PN, Italy.
          Article
          onc2011621 NIHMS378688
          10.1038/onc.2011.621
          3433647
          22266873
          a4da43c9-15fc-4fea-81ee-dc6663c26ff2
          History

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