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      Lipase inhibitory and LDL anti-oxidative triterpenes from Abies sibirica.

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          Abstract

          A methanol extract of Abies sibirica Ladeb, a Mongolian medicinal plant, had an inhibitory effect on both lipase activity in mouse plasma and LDL anti-oxidative activity, which are preventative factors for arteriosclerosis. The extract was fractionated by silica gel column chromatography and its active constituents were sought. From lipid soluble fractions, 20 terpenoids including seven hitherto unknown triterpenes were isolated. The latter triterpenes had either a γ-lactone ring with a lactol or a derivative thereof. Their chemical structures were determined by spectroscopic methods. The lipase inhibitory activity and LDL anti-oxidative activity of these compounds were evaluated. Some constituents (either lipase inhibitory or LDL anti-oxidative activities) had moderate inhibitory activities.

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          Author and article information

          Journal
          Phytochemistry
          Phytochemistry
          Elsevier BV
          1873-3700
          0031-9422
          Feb 2013
          : 86
          Affiliations
          [1 ] Department of Pharmacognosy, Tohoku Pharmaceutical University, Aoba-ku, Sendai, Japan.
          Article
          S0031-9422(12)00491-8
          10.1016/j.phytochem.2012.11.017
          23261031
          a4ee5aaa-e556-4234-bf74-5a753fd9b931
          History

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